Interleukin 2 induction in Lyt 1+ 23- T cells from Listeria monocytogenes-immune mice.
نویسندگان
چکیده
Peritoneal exudate T lymphocytes from mice experimentally infected with the intracellular bacterium Listeria monocytogenes secreted high interleukin 2 activities after interaction with syngeneic normal macrophage presenting listerial antigen in vitro. L. monocytogenes-immune cells secreting IL 2 were radioresistant and bore the phenotype Thy 1(+) Lyt 1(+)23(-).
منابع مشابه
Developmental interrelationship of specific Lyt 123 and Lyt 1 cell sets in expression of antibacterial immunity to Listeria monocytogenes.
Lyt phenotypes of peritoneal exudate T lymphocytes from Listeria monocytogenes-immune mice were determined with respect to their capacity to confer protection upon local or systemic transfer. It is shown that, locally, Lyt 1 T cells provide protection, whereas only unselected native populations, containing adequate numbers of Lyt 123 T cells, were effective in transferring systemic protection. ...
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Lyt-2+ T cell clones were established from Listeria monocytogenes-infected mice. The clones secreted IFN-gamma after stimulation with spleen cells from L. monocytogenes-infected mice plus IL-2. Spleen cells from normal mice were not stimulatory. Furthermore, cloned T cells lysed L. monocytogenes-infected macrophages. Cytolysis was antigen-specific and H-2K-restricted. These findings suggest a r...
متن کاملSpecific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens
Specific anti-Lyt antisera and complement were used to determine the Lyt phenotype of peritoneal exudate T lymphocytes from Listeria monocytogenes-immune mice. It was found that Lyt 123+ T cells are crucially involved both in protection against listerial infection and in delayed-type hypersensitivity (DTH) to listerial antigens. Thus, both functions critically depend on a T-cell subclass phenot...
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Infections by facultative intracellular bacteria result in inflammatory tissue responses, such as delayed-type hypersensitivity (DTH), and the focal accumulation of mononuclear cells within granulomatous lesions (1, 2) . Both DTH and granuloma formation depend on an intact T cell response and have so far been accepted to be indispensable for protection against facultative intracellular bacteria...
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Background: The use of dendritic cells (DCs) as a cellular adjuvant provides a promis-ing approach in immunotherapy of cancer. It has been demonstrated that Listeria mono-cytogenes activated DCs pulsed ex vivo with tumor antigens trigger a systemic Th1-biased specific immune response and a single dose of this vaccine will cause a consider-able anti tumor immunity. Objective: The present study w...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 37 3 شماره
صفحات -
تاریخ انتشار 1982